Molecular Synthetic
Biology Laboratory
분자합성생물학 및 단백질화학 연구실
주요 발표 논문
Major Publications
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Site-specific Protein Modification
Science, 354(6312):623-626. (2016)
Phosphoserine Incorporation
Science, 333(6046): 1151-1154 (2011)
Angew. Chem. Int. Ed. 52(22): 5771-5775. (2013)
Nε-Acetyl-L-Lysine Incorporation
Nat. Comm. 8:14568. (2017)
FEBS Lett, 586(6):729-33. (2012)
Protein Labeling & Drug Screening
Angew. Chem. Int. Ed. 62(7):e202214815. (2022)
Adv. Sci. 2302253 (2023)
연구 분야
Research Area
Site-specific Protein Modification
-"Marking-Activation-Coupling" approach to attach various functional handles to protein
-Site-specific, authentic protein modification
Genetic Incorporation of
Unnatural Amino Acids into Proteins
- Development of new method for incorporation of unnatural amino acid into proteins
- Design and engineering of new translation machinery for genetic code expansion
Phosphoserine Incorporation
Application of synthetic biology techniques to basic cell biology and applied medical science
- Detailed mapping of protein kinase signaling network
- Anti-cancer drug design based on activated target protein-ligand structure/modeling
- High-throughput screening of kinase inhibitors for cancer therapy
Protein Engineering and Directed Evolution
- Development of new strategy for the redesign of proteins with novel function
- Rational design of proteins based on structure analysis
- Molecular evolution of proteins for enhanced properties
연락하기
대전광역시 유성구 대학로 291 (구성동)
한국과학기술원 기초과학동 (E6-6) 519호
82) 042-350-2853
